English: Fig. 1. Symptom inventory outcomes in patients with cerebral folate deficiency before and after treatment with folinic acid. Sixteen participants with CFD, and treated with folinic acid, showed reductions in SIQ scores, and 7 out of 8 participants showed reductions in BDI scores (1 participant showed an increased BDI score by 1 point following treatment). In patients with CFD, average BDI score decreased from 30.94 (s.d. 9.82) to 18.5 (s.d. 12.09), t tests revealed that the change was statistically significant, t = 3.83, p < 0.003. Average Suicidal Ideation Questionnaire score decreased from 40.31 (s.d. 20.15) to 22.88 (s.d. 16.94), t tests revealed that the change was statistically significant, t = 3.03, p < 0.01.